STUDIES ON COMPLEMENT FIXATION IN TUBERCULOSIS. III

Studies on Complement Fixation in Tuberculosis. Iii

The prolonged extraction of the tubercle bacillus with boiling ethyl alcohol, followed by one or more reprecipitations by chilling the hot alcoholic solution, easily yields a preparation very active as antigen in the complement fixation reaction. This preparation gives a precipitation reaction with high dilution of the normal blood serum of a number of species. The precipitation reaction presen...

Studies on Complement Fixation

It is shown by complement fixation studies with protein antigens and specific immune rabbit sera that the rate of fixation of complement is determined by the concentration of antibodies in the immune sera, that the greater part of fixation of complement takes place during the 1st hour, and that fixation is practically completed at the end of 4 hours at ice box temperature. It is further shown t...

Studies on a complement fixation test for Herpes simplex.

Although the neutralization test is, in general, satisfactory for immunologic studies with a diversity of viruses, it is cumbersome and expensive. The complement fixation test, in contrast, is simple and rapid and has been successfully applied to a number of viral diseases, especially for diagnostic purposes. In the case of herpes simplex virus infections, however, the literature concerning the...

Indirect Complement Fixation in Foot-and-Mouth Disease

On Complement-fixation in Malignant Disease

Through the researches of Wassermann and his collaborators it has been established that syphilitic sera may contain substances which in the presence of other substances derived from syphilitic organs are capable of fixing complement, so that upon the subsequent addition of red corpuscles and homologous hemolytic amboceptor hemolysis is impeded. This phenomenon was originally interpreted as mean...